Welcome to the Baldwin Lab homepage
We are a biomolecular NMR research group based in the Department of Chemistry at the University of Oxford, and we are interested in the biophysical basis of function, and malfunction, of proteins in health and disease.
We combine advanced solution and solids NMR spectroscopy techniques - including Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion experiments, shown below - with complementary methods such as ion-mobility mass spectrometry (MS) and electron microscopy in order to study the structure and dynamics of proteins, and relate this to their behaviour in the cell. Together, these techniques provide information about protein secondary, tertiary, and quaternary structures, in addition to details regarding protein motions ranging from picoseconds through hours.
CPMG relaxation dispersion experiments probe protein motions on the microsecond-millisecond timescale and enable quantification of the populations, kinetics, and structures of thermodynamically “excited” conformational states.
In combination with methyl-TROSY and CPMG relaxation dispersion experiments, native MS and ion-mobility MS data can generate models of polydisperse protein oligomers that satisfy local (NMR) and global (MS) restraints.
We currently have postdoc positions available! Click here for more information
Part II projects are also available.
RESEARCH INTERESTS (click image for more info):
Solutions and solids NMR spectroscopy
Native mass spectrometry and electron microscopy