40

Proline isomerization in the C-terminal region of HSP27
Alderson R, Benesch JLP, Baldwin AJ,
Cell and cell stress (in press) 2017

39

magma_toc
Automatic assignment of methyl-NMR spectra of supra-molecular machines using graph theory
Pritisanac I, Degiacomi M, Alderson R, Carneiro M, Eiso AB, Siegal G, Baldwin AJ,
J. Am. Chem. Soc. (in press) 2017

38

rogen_toc
Monitoring the disassembly of virus-like particles by 19F-NMR
Leung RLC, Robinson MDM, Alaa AAA, Karunanithy G, Lyons B, Raj R, Raoufmoghaddam S, Mohammed S, Claridge TDW, Baldwin AJ, Davis BG
J. Am. Chem. Soc. (2017) 139 5277
link

37

gupta_toc
The role of interfacial lipids in stabilising membrane protein oligomers
Gupta K, Donlan JAC, Hopper JTS, Uzdavinys P, Landreh M, Struwe WB, Drew D, Baldwin AJ, Stansfeld PJ, Robinson CV
Nature (2017) 541, 421–424
link

36

tom_toc
Post-translational mutagenesis: a chemical strategy for exploring protein side-chain diversity
Wright TH, Bower BJ, Chalker JM, Bernardes GJL, Wiewiora R, Ng WL, Raj R, Faulkner S, Vallée MRJ, Phanumartwiwath A, Coleman OD, Thézénas ML, Khan M, Galan SRG, Lercher L, Schombs MW, Gerstberger S, Palm-Espling MEP, Baldwin AJ, Kessler BM, Claridge TDW, Mohammed S, Davis BG
Science (2016) 354, 596 and aag1465 2016
pdf

Featured in a Perspective in Science, a Research Highlight in Nature Methods and in an Article in Chemical & Engineering News.

35

Determination of an optimally sensitive and specific Chemical Exchange Saturation Transfer MRI quantification metric in relevant biological phantoms
Ray KJ, Larkin JR, Tee YK, Khrapitchev AA, Karunanithy G, Barber M, Baldwin AJ, Chappell MA, Sibson NR
NMR in biomedicine (2016) 29 (11), 1624-1633
pdf
supp

34

tocFig
ChemComm-Cover-design

Harnessing NMR relaxation interference effects to characterise supramolecular assemblies
Karunanithy G, Cnossen A, Müller H, Peeks MD, Rees NH, Claridge TDW, Anderson HL, Baldwin AJ
Chemical Communications (2016) 52, 7450-7453
pdf
supp
(Cover Art, right)

33

160314 - TOC

Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters
Nott TJ, Craggs TD, Baldwin AJ
Nature Chemistry (2016) 8, 569-575
link
Nature Chemistry News and Views link
Editors choice, Science link
Health Medicinet link
Phys.org link

32

Pasted Graphic

Quantifying the stabilizing effects of protein-ligand interactions in the gas phase
Allison TM, Reading E, Liko I, Baldwin AJ, Laganowsky A, Robinson CV
Nature Communications (2015) DOI: 10.1038/ncomms9551
pdf

31

starch_toc
Investigating the Mechanisms of Amylolysis of Starch Granules by Solution-State NMR
Baldwin AJ, Egan D, Warren F, Barker PD, Dobson CM, Butterworth P, Ellis P
Biomacromolecules (2015) 16, 1614−1621
pdf

30

unidec
Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles
Marty MT, Baldwin AJ, Marklund EG, Hochberg GKA, Benesch JLP, Robinson CV
Anal. Chem. (2015) 87 (8) 4370-4376
pdf

29

impact

Collision Cross Sections for Structural Proteomics
Markland EG, Degiacomi MT, Robinson CV, Baldwin AJ, Benesch JLP
Structure (2015) 23(4):791-9
pdf

28

Combining tandem mass spectrometry with ion mobility separation to determine the architecture of polydisperse proteins
Shepherd DA, Marty MT, Giles K, Baldwin AJ, Benesch JLP
Int. J mass spec. (2015) 377(1)
pdf

27

blob_toc
Phase transition of a disordered Nuage protein generates environmentally responsive membraneless organelles
Nott TJ, Petsalaki E, Farber P, Jervis D, Fussner E, Plochowietz A, Craggs T, Bazett-Jones DP, Pawson T, Forman-Kay JP, Baldwin AJ
Molecular Cell (2015) 57 936-947
pdf
supp

26

lipidConnection
Membrane proteins bind lipids selectively to modulate their structure and function
Laganowsky A, Reading E, Allison T, Ulmschneider MB, Degiacomi MT, Baldwin AJ, Robinson CV
Nature (2014), 510 7503, 172-175
link




25

The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity
Hochberg GKA, Ecroyd H, Liu C, Cox D, Csciod D, Sawaya MR, Colliera MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JLP, Laganowsky A
PNAS (2014) 111, E1562-70
pdf
supp
commentary

24

cpmg_toc
An exact solution for R2,eff in CPMG experiments in the case of two site chemical exchange
Baldwin AJ
JMR (2014), 244, 114-124
pdf
supp
See Resources for implementation in C and python.

23

An R expression for a spin in chemical exchange between two sites with unequal transverse relaxation rates
Baldwin AJ, Kay LE
J. Biol. NMR (2013), 55:211-218
pdf

22

C-terminal Interactions Mediate the Quaternary Dynamics of αB-crystallin
Hilton GR, Hochberg GKA, Laganowsky A, McGinnigle SI, Baldwin AJ, Benesch JLP
Phil. Trans. R. Soc. B. (2013) 368 20110405
pdf
supp

21

Small heat-Shock proteins: paramedics of the cell
Hilton GR, Lioe H, Stengel F, Baldwin AJ, Benesch JLP
Top. Curr. Chem. (2013) 328:69-98
pdf

20

Twisting Transition between Crystalline and Fibrillar Phases of Aggregated Peptides
Knowles TPJ, Simone AD, Fitzpatrick AW, Baldwin AJ, Meehan S, Rajah L, Vendruscolo M, Welland ME, Dobson CM, Terentjev EM
PRL (2012) 109(15) 15101
pdf

19

Dynamic binding
Baldwin AJ, Kay LE
Nature (2012) 488(7410): 165-6
pdf

18

structure_toc
Probing dynamic conformations of the high molecular weight αB-crystallin heat shock protein ensemble by NMR spectroscopy
Baldwin AJ, Walsh P, Hansen DF, Hilton GR, Benesch JLP, Sharpe S, Kay LE
J. Am. Chem. Soc. (2012) 134(37) 15343-50
pdf
supp

17

Dissecting heterogeneous molecular chaperone complexes using a mass spectrum deconvolution approach
Baldwin AJ*, Stengel F*, Bush MF, Hilton GR, Lioe H, Basha E, Jaya N, Vierling E, Benesch JLP
Chem & Biol. (2012) 19: 599-607
pdf
supp
commentary Slingsby C, Clark AR

16

Measurement of the signs of methyl chemical shift differences between ground and excited protein states by R: an application to αB-crystallin
Baldwin AJ, Kay LE
J. Biol. NMR (2012) 53(1): 1
pdf

15

The morphology of decorated amyloid fibers is controlled by the conformation and position of the displayed protein
Forman CJ, Nickson AA, Anthony-Cahill SJ, Baldwin AJ, Kaggwa G, Feber U, Sheikh K, Jarvis SP, Barker PD
ACS Nano. (2012) 6: 1332-1346
pdf
supp

14

The polydispersity of αB-crystallin is rationalised by an interconverting polyhedral architecture
Baldwin AJ, Lioe H, Hilton GR, Baker LA, Rubinstein JL, Kay LE, Benesch JLP
Structure (2011) 19: 1855-63
pdf
supp

13

jmb_cover
Quaternary dynamics of αB-crystallin as a direct consequence of localised tertiary fluctuations in the C-terminus
Baldwin AJ, Hilton GR, Lioe H, Bagnéris C, Benesch JLP, Kay LE
J. Mol. Biol. (2011) 413: 310-20
pdf
supp
commentary Carver JA

12

jmb_cover
αB-crystallin polydispersity is a consequence of unbiased quaternary dynamics
Baldwin AJ, Lioe H, Robinson CV, Kay LE, Benesch JLP
J. Mol. Biol. (2011) 413: 297-309
pdf
supp
commentary Carver JA

11

meta_toc
Metastability of native proteins towards amyloid formation
Baldwin AJ, Knowles TPJ, Devlin GL, Shammas SL, Fitzpatrick AW, Waudby C, Mossuto MF, Meehan S, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM
JACS (2011) 133: 14160-14163
pdf
supp
commentary Thirumalai D, Reddy G, Nature Chemistry

10

Perturbation of the stability of amyloid fibrils through alteration of electrostatic interactions
Shammas S, Knowles TPJ, Baldwin AJ, MacPhee CE, Welland ME, Dobson CM, Devlin GL
Biophysical Journal (2011) 100: 2783-2791
pdf
supp

9

hsp26_toc

The quaternary organization and dynamics of the molecular chaperone HSP26 are thermally regulated
Benesch JLP, Aquilina JA, Baldwin AJ, Rekas A, Stengel F, Lindner R, Basha E, Devlin G, Horwitz J, Vierling E, Carver JA, Robinson CV
Chem. Biol. (2010) 17: 1008-17
pdf

8

chd2_toc
CHD2 methyl group probes ms timescale exchange in proteins by 1H relaxation dispersion: An application to proteosome gating residue dynamics
Baldwin AJ, Religa TLR, Hansen DF, Bouvignies G, Kay LE
JACS (2010) 132: 10992-5
pdf
supp

7

Quaternary dynamics and plasticity underlie small heat shock protein chaperone function
Stengel, F, Baldwin, AJ, Painter AJ, Jaya N, Basha E, Kay LE, Vierling E, Robinson CV, Benesch JLP
Proc. Natl. Acad. Sci. U.S.A. (2010), 107: 2007-12
pdf
supp
commentary, Eyles S, Gierasch LM

6

NMR spectroscopy brings invisible protein states into focus
Baldwin AJ, Kay LE
Nature Chemical Biology (2009) 5: 808-814
pdf

5

rdc_toc
Measurement of methyl Axis orientations in invisible excited states of proteins by relaxation dispersion NMR spectroscopy
Baldwin AJ, Hansen DF, Vallurupalli P, Kay LE
JACS (2009) 131: 11939-11948
pdf
supp

4

length_toc
Measurement of amyloid fibril length distribution by inclusion of rotational motion in solution NMR diffusion measurements
Baldwin AJ, Anthony-Cahill SJ, Knowles TPJ, Lippens G, Christodoulou J, Barker PD, Dobson CM
Angewandte Chemie, Int Ed. (2008) 47: 3385-3387
pdf
supp

3

Characterisation of amyloid fibril formation by the small heat-shock protein αB-crystallin and manipulation of the protofilament substructure
Meehan S, Knowles TPJ, Baldwin AJ, Smith J, Squires AM, Clements P, Treweek TM, Ecroyd H, Tartaglia GG, Vendruscolo M, MacPhee CM, Dobson CM, Carver JA
J Mol. Biol. (2007) 372: 470-484
pdf

2

Contribution of rotational diffusion to PFGSE measurements
Baldwin AJ, Christodoulou J, Dobson CM, Lippens G.
J. Chem. Phys. (2007) 127: 114505-8
pdf

1

cytochrome_toc
Cytochrome display on amyloid fibrils
Baldwin AJ, Bader R, Christodoulou J, MacPhee CE, Barker PD, Dobson CM
JACS (2006) 128: 7 2162
pdf
supp

PhD thesis

Solution-state NMR studies of amyloid fibrils
Baldwin AJ
pdf