Morgan Wright

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Morgan is a DPhil student interested in the interactions between disordered proteins and small molecules. Due to the large conformational ensemble exhibited by disordered proteins, characterisation of disordered protein-ligand complexes by classical techniques such as electron-microscopy and crystallography are more challenging, whereas NMR is an ensemble technique ideal for characterising these interactions. Morgan uses Saturation Transfer Difference (STD) NMR to study these interactions, with a particular interest in disordered proteins with roles in neurodegenerative disease, such as ɑ-synuclein and tau, and their interactions with neurotransmitters and aggregation inhibitors. Identifying these complexes expands our understanding of biochemistry and helps towards finding preventative treatments for neurodegenerative diseases. In his spare time, Morgan enjoys baking bread and writing/recording music.