My research looks at the nuclear spin physics involved in NMR, focussing on how molecular dynamics can bring NMR magnetisation back to equilibrium (NMR relaxation). When studying large proteins using NMR, the resolution in their spectra is poor due to fast NMR relaxation. NMR is a fantastic technique for studying the dynamics of molecules in solution, but it is difficult to study the dynamics of larger proteins using NMR due to the poor resolution. By looking at the mathematical theory surrounding relaxation, we hope to develop new techniques to increase the resolution of these spectra, enabling larger proteins and complexes to be studied more routinely.

In addition to the project above, I am aiming to perform protein expression and purification of biologically important proteins, particularly those important to protein folding or aggregation. These will then be analysed by NMR to determine their structures and dynamics.

Outside of research, I like to go hiking or to the gym as it helps clear my mind. I can also be often found at one of the many pubs or bars that Oxford has to choose from.

Yaxin’s research focus on characterizing the transition of IDPs from monomers to oligomers and the subsequent formation of phase-separated droplets. Studying oligomers separately could potentially reveal mechanisms by which IDP transitions through distinct states—from monomers to oligomers to phase-separated droplets—providing insights into the control points of LLPS and aggregation.

In his part II research project Ben investigated the properties of phase separated protein droplets, and used NMR techniques to do this. Outside of the research, he plays for Oxford Universities Quadball Club. We are happy that Ben decided to stay on for his Dphil!

 Suzanne is a Part II excited about all things NMR! Her project will include working on Seedless, the group's on-the-fly NMR pulse optimisation program, and eventually creating a pulse-optimised TOCSY/decoupling sequence. When not at her desk, she can be found at the climbing gym, or knitting/crocheting her next fibre arts project.

Imogen has joined the Baldwin group as a Part II student. She is aiming to use NMR techniques to probe misfolding protein interactions that are involved in neurodegenerative diseases such as Alzheimer’s. 
Outside of the lab, Imogen enjoys designing and sewing clothes for herself and her family / friends. Her favourite creation so far has been a black silk ball gown, which she proudly wore to the Merton Winter Ball. 

Petra joined as a Part II student, hoping to study tau aggregation inhibition interactions using NMR techniques, with a particular interest in the overall neurodegenerative disease space. Outside of the lab, Petra was previously part of the Oxford University Volleyball team, Oxford Thai Society president, and enjoys spending time cooking, exercising, and playing cards at the pub with her friends.